Handbook of COVID-19 Prevention and Treatment, sponsored by Jack Ma Foundation and Alibaba Foundation and compiled by a panel of medical experts from the First Affiliated Hospital, Zhejiang University School of Medicine (FAZHU) according to their clinical experience in fighting the pandemic, was officially released on March 18.
Live Stats: Follow C19 Pandemic in Live
According to the linked study: "A single ventilator may be quickly modiﬁed to ventilate four simulated adults for a limited time. The volumes delivered in this simulation should be able to sustain four 70-kg individuals. Whilefurther study is necessary, this pilot study suggests signiﬁcant potential for the expanded use of a singleventilator during cases of disaster surge involving multiple casualties with respiratory failure".
VIDEO: A Brussels hospital developed an emergency ventilator made from a Decathlon snorkelling mask to help mitigate any equipment shortages during the #coronavirus pandemic pic.twitter.com/YN5HoWEiTO— AFP news agency (@AFP) March 28, 2020
DIY: Build and print your own open source ventilator with 3D printer.
Alors que le #COVID_19 continue à se répandre dans le monde, une équipe de 300 bénévoles a créé en une semaine un respirateur artificiel imprimable en 3D. Peu coûteux, il vise à pallier le manque dans les hôpitaux. Cerise sur le gâteau? Il est entièrement «open source». THREAD— Lucas Philippoz (lph) (@LPhilippoz) March 20, 2020
Chloroquine for COVID-19
Hydroxychloroquine (Plaquenil) for COVID-19
Prescription drug developed by Fujifilm Toyama Chemical – also known as Avigan – in 2014, it had produced encouraging outcomes in clinical trials in Wuhan and Shenzhen involving 340 patients. Patients who were given the medicine in Shenzhen turned negative for the virus after a median of four days after becoming positive. X-rays confirmed improvements in lung condition in about 91% of the patients who were treated with favipiravir, compared to 62% or those without the drug. Japanese health ministry source suggested the drug was not as effective in people with more severe symptoms. “We’ve given Avigan to 70 to 80 people, but it doesn’t seem to work that well when the virus has already multiplied”. The same limitations had been identified in studies involving coronavirus patients using a combination of the HIV antiretrovirals lopinavir and ritonavir, the source added. It is efficient againt Ebola and was used on 2016 in Guinea for this purpose.
A collaborative study led by Monash University's Biomedicine Discovery Institute (BDI) in Melbourne, Australia, with the Peter Doherty Institute of Infection and Immunity (Doherty Institute), has shown that an anti-parasitic drug already available around the world kills the virus within 48 hours. The Monash Biomedicine Discovery Institute's Dr Kylie Wagstaff, who led the study, said the scientists showed that the drug, Ivermectin, stopped the SARS-CoV-2 virus growing in cell culture within 48 hours. "We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it."
Kaletra (alone or with interferon beta) from AbbVie, currently tested in France
On 18-MAR-2020, a study published in New England Journal of Medicine reveals that Kaletra is NOT efficient on Covid-19
Cyclodextrin is used in Remdesivir as well, associated with Ginkgo in recent studies, results have concluded so far that: "Finally, with due attention to the high effectiveness function of terpenoids, we can conclude that these compounds may be considered as effective COVID 19 antiprotease drugs".
Intravenous treatment of 6000mg per day for serious case and up to 12000mg for critical cases seem to provide good results against Covid19.
UPDATE 25/03/2020: New study in prestigeous publication "TheLancet" show new evidence of efficiency of high dose Vitamin C, the NYpost reported it as well.
The "Institut de recherches cliniques de Montréal (IRCM)" might found a natural extract that could defeat Covid-19. Dr Michel Chrétien lead the team behind this discovery, study in China is or will be ongoing soon. Seems efficient againt Ebola.