Treatments for Covid-19 disease

from SARS-CoV-2 (ex 2019-nCoV)

DISCLAIMER: This site does NOT make any medical recommendation, it represents a list of on-going studies and their initial test results in treating the Covid-19 disease.

C19 Handbook | PDF

Handbook of COVID-19 Prevention and Treatment, sponsored by Jack Ma Foundation and Alibaba Foundation and compiled by a panel of medical experts from the First Affiliated Hospital, Zhejiang University School of Medicine (FAZHU) according to their clinical experience in fighting the pandemic, was officially released on March 18.
Live Stats: Follow C19 Pandemic in Live


War Med | DIY

According to the linked study: "A single ventilator may be quickly modified to ventilate four simulated adults for a limited time. The volumes delivered in this simulation should be able to sustain four 70-kg individuals. Whilefurther study is necessary, this pilot study suggests significant potential for the expanded use of a singleventilator during cases of disaster surge involving multiple casualties with respiratory failure".


DIY: Build and print your own open source ventilator with 3D printer.



Hydroxychloroquine / Chloroquine

Chloroquine for COVID-19

Hydroxychloroquine (Plaquenil) for COVID-19


Remdesivir

  • Remdesivir (GS-5734, RDV) is not FDA-approved and is available for investigational use only
    • Is a nucleotide analog antiviral
    • Has activity against Ebola virus, MERS, and SARS
    • Has drug-drug interactions via the liver, so would not be expected to be given with LPV/r
      • Guidance from Gilead was that once remdesivir is initiated, any experimental anti-COVID-19 therapies must be ceased
    • Available intravenous only
      • Study dose in adults: RDV 200 mg loading dose on day 1 is given, followed by 100 mg iv once-daily maintenance doses for 9 days
        • Review study protocols here
  • In preparing to request investigational remdesivir, collecting the following information ahead of time may be helpful:
    • Prescriber name, address, email, and phone number associated with the treatment center
    • Professional designation (ie, MD) or qualifications of requester including medical license number
    • Institution/ hospital name, address, email, and phone number
    • Shipping information (including pharmacy hours)
    • Patient case information, including previous or current treatments and clinical status
  • There are many exclusion criteria for remdesivir
  • Remdesivir clinical trials
  • Email to contact Gilead compassionate use: compassionateaccess@gilead.com

Favipiravir

Prescription drug developed by Fujifilm Toyama Chemical – also known as Avigan – in 2014, it had produced encouraging outcomes in clinical trials in Wuhan and Shenzhen involving 340 patients. Patients who were given the medicine in Shenzhen turned negative for the virus after a median of four days after becoming positive. X-rays confirmed improvements in lung condition in about 91% of the patients who were treated with favipiravir, compared to 62% or those without the drug. Japanese health ministry source suggested the drug was not as effective in people with more severe symptoms. “We’ve given Avigan to 70 to 80 people, but it doesn’t seem to work that well when the virus has already multiplied”. The same limitations had been identified in studies involving coronavirus patients using a combination of the HIV antiretrovirals lopinavir and ritonavir, the source added. It is efficient againt Ebola and was used on 2016 in Guinea for this purpose.


Ivermectin | Stromectol

A collaborative study led by Monash University's Biomedicine Discovery Institute (BDI) in Melbourne, Australia, with the Peter Doherty Institute of Infection and Immunity (Doherty Institute), has shown that an anti-parasitic drug already available around the world kills the virus within 48 hours. The Monash Biomedicine Discovery Institute's Dr Kylie Wagstaff, who led the study, said the scientists showed that the drug, Ivermectin, stopped the SARS-CoV-2 virus growing in cell culture within 48 hours. "We found that even a single dose could essentially remove all viral RNA by 48 hours and that even at 24 hours there was a really significant reduction in it."


Kaletra | INEFFICIENT

Kaletra (alone or with interferon beta) from AbbVie, currently tested in France
On 18-MAR-2020, a study published in New England Journal of Medicine reveals that Kaletra is NOT efficient on Covid-19


Cyclodextrin | Ginkgo

Cyclodextrin is used in Remdesivir as well, associated with Ginkgo in recent studies, results have concluded so far that: "Finally, with due attention to the high effectiveness function of terpenoids, we can conclude that these compounds may be considered as effective COVID 19 antiprotease drugs".


Vitamine C Liposomale | IVC

Intravenous treatment of 6000mg per day for serious case and up to 12000mg for critical cases seem to provide good results against Covid19.
UPDATE 25/03/2020: New study in prestigeous publication "TheLancet" show new evidence of efficiency of high dose Vitamin C, the NYpost reported it as well.


Quercetin

The "Institut de recherches cliniques de Montréal (IRCM)" might found a natural extract that could defeat Covid-19. Dr Michel Chrétien lead the team behind this discovery, study in China is or will be ongoing soon. Seems efficient againt Ebola.


List of Other Potential Therapies Original Source

  • Tocilizumab (Actemra) - Novel Coronavirus Pneumonia Diagnosis and Treatment Plan (Provisional 7th Edition) - Effective Treatment of Severe COVID-19 Patients with Tocilizumab - Tocilizumab (Actemra) Package Insert
  • Nitazoxanide - Source: Nature 10-FEV-2020
  • Azithromycin
  • Intravenous Immunoglobulin
  • Thalidomide
  • Fingolamid (FTY720)
  • Carrimycin
  • Bromhexine HCl
  • Ecluzumab (Soliris)
  • Bevacizumab (Avastin)
  • Sarilumab (Kevzara)
  • Nitrous oxide gas
  • Tiecoplanin
  • ASC09F
  • Xainping
  • Arbidol - Arbidol Combined With LPV/r Versus LPV/r Alone Against Corona Virus Disease 2019: a Retrospective Cohort Study
  • Darunavir/ cobicistat (Prezcobix)
  • Danoprevir (Ganovo)
  • Pirfrenidone (Esbriet)
  • Ribavirin - Stability of Extemporaneous Oral Ribavirin Liquid Preparation
  • Interferon alfa 2b
  • Ciclesonide (Zetonna) - The inhaled corticosteroid ciclesonide blocks coronavirus RNA replication by targeting viral NSP15
  • Indomethacin - Indomethacin Has a Potent Antiviral Activity Against SARS Coronavirus - Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2α kinase PKR
  •  Zinc - Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture - Chloroquine Is a Zinc Ionophore